8EJK: Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc

PDB ID: 8EJKDownload
MMDB ID: 230543
PDB Deposition Date: 2022/9/17
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8EJK: pentameric; determined by author
Molecular Components in 8EJK
Label Count Molecule
Proteins (5 molecules)
1
a Modified Guanine Nucleotide-binding Protein G(q) Subunit Alpha
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
1
Scfv16
Molecule annotation
1
Free Fatty Acid Receptor 1
(Gene symbol: FFAR1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303