8EFJ: A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds

PDB ID: 8EFJDownload
MMDB ID: 235771
PDB Deposition Date: 2022/9/8
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.31  Å
Source Organism:
Similar Structures:
Biological Unit for 8EFJ: monomeric; determined by author
Molecular Components in 8EFJ
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 14
(Gene symbol: Mapk14)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
octyl beta-D-glucopyranosideoctyl beta-D-glucopyranoside
2
1
(4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide(4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303