8ECC: Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA

PDB ID: 8ECCDownload
MMDB ID: 241248
PDB Deposition Date: 2022/9/1
Updated in MMDB: 2026/03
Experimental Method:
x-ray diffraction
Resolution: 2.44  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8ECC: hexameric; determined by author and by software (PISA)
Molecular Components in 8ECC
Label Count Molecule
Proteins (2 molecules)
2
Cyclic Gmp-amp Synthase
Molecule annotation
Nucleotides(4 molecules)
4
Palindromic Dna18
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
2
2
MAGNESIUM IONMAGNESIUM ION
3
2
ZINC IONZINC ION
4
1
[[(2~{R},3~{R},4~{R},5~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate[[(2~{R},3~{R},4~{R},5~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303