8EAE: Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI

PDB ID: 8EAEDownload
MMDB ID: 237090
PDB Deposition Date: 2022/8/29
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.56  Å
Source Organism:
DNA molecule▼
Similar Structures:
Biological Unit for 8EAE: hexameric; determined by author and by software (PISA)
Molecular Components in 8EAE
Label Count Molecule
Proteins (2 molecules)
2
Cyclic Gmp-amp Synthase
Molecule annotation
Nucleotides(4 molecules)
4
Palindromic Dna18
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
[[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (Link to PubChem not yet available)[[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
2
2
ZINC ION (Link to PubChem not yet available)ZINC ION
3
2
MAGNESIUM ION (Link to PubChem not yet available)MAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303