8DTJ: Human NAMPT in complex with small molecule activator ZN-43-S

PDB ID: 8DTJDownload
MMDB ID: 227632
PDB Deposition Date: 2022/7/25
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.118  Å
Source Organism:
Similar Structures:
Biological Unit for 8DTJ: dimeric; determined by author and by software (PISA)
Molecular Components in 8DTJ
Label Count Molecule
Proteins (2 molecules)
2
Nicotinamide Phosphoribosyltransferase
(Gene symbol: NAMPT)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
PHOSPHATE IONPHOSPHATE ION
2
3
GLYCEROLGLYCEROL
3
2
(3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide(3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide
4
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303