8DSO: Structure of cIAP1, BTK and BCCov

PDB ID: 8DSODownload
MMDB ID: 227627
PDB Deposition Date: 2022/7/22
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.334  Å
Source Organism:
Similar Structures:
Biological Unit for 8DSO: dimeric; determined by author
Molecular Components in 8DSO
Label Count Molecule
Proteins (2 molecules)
1
Tyrosine-protein Kinase BTK
(Gene symbol: BTK)
Molecule annotation
1
Baculoviral IAP Repeat-containing Protein 2
(Gene symbol: BIRC2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
(4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide bound form(4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide bound form
2
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303