8DSM: Human NAMPT in complex with inhibitor ZN-4-3

PDB ID: 8DSMDownload
MMDB ID: 233563
PDB Deposition Date: 2022/7/22
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 8DSM: dimeric; determined by author and by software (PISA)
Molecular Components in 8DSM
Label Count Molecule
Proteins (2 molecules)
2
Nicotinamide Phosphoribosyltransferase
(Gene symbol: NAMPT)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
(3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide(3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide
2
2
PHOSPHATE IONPHOSPHATE ION
3
2
CHLORIDE IONCHLORIDE ION
4
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303