8DSD: Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-S

PDB ID: 8DSDDownload
MMDB ID: 227621
PDB Deposition Date: 2022/7/22
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.429  Å
Source Organism:
Similar Structures:
Biological Unit for 8DSD: dimeric; determined by author and by software (PISA)
Molecular Components in 8DSD
Label Count Molecule
Proteins (2 molecules)
2
Nicotinamide Phosphoribosyltransferase
(Gene symbol: NAMPT)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
NICOTINAMIDENICOTINAMIDE
2
2
PHOSPHATE IONPHOSPHATE ION
3
2
(3S)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide(3S)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide
4
3
CHLORIDE IONCHLORIDE ION
5
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303