8DO1: Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F

PDB ID: 8DO1Download
MMDB ID: 230531
PDB Deposition Date: 2022/7/12
Updated in MMDB: 2023/09
Experimental Method:
electron microscopy
Resolution: 3.01  Å
Source Organism:
Similar Structures:
Biological Unit for 8DO1: trimeric; determined by author
Molecular Components in 8DO1
Label Count Molecule
Proteins (3 molecules)
1
Protein Transport Protein Sec61 Subunit Alpha Isoform 1
(Gene symbol: SEC61A1)
Molecule annotation
1
Protein Transport Protein Sec61 Subunit Gamma
(Gene symbol: SEC61G)
Molecule annotation
1
Protein Transport Protein Sec61 Subunit Beta
(Gene symbol: SEC61B)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
[(1~{S},3~{R},4~{S},5~{R},6~{R},8~{R},10~{S},23~{R},24~{R},25~{R},26~{R})-5-acetyloxy-6-methyl-4,26-bis(oxidanyl)-17,20-bis(oxidanylidene)-10-pentyl-24-[(~{E})-3-phenylprop-2-enoyl]oxy-2,7,9,21,27-pentaoxatricyclo[21.3.1.0^{3,8}]heptacosan-25-yl] (~{E})-2-methylbut-2-enoate[(1~{S},3~{R},4~{S},5~{R},6~{R},8~{R},10~{S},23~{R},24~{R},25~{R},26~{R})-5-acetyloxy-6-methyl-4,26-bis(oxidanyl)-17,20-bis(oxidanylidene)-10-pentyl-24-[(~{E})-3-phenylprop-2-enoyl]oxy-2,7,9,21,27-pentaoxatricyclo[21.3.1.0^{3,8}]heptacosan-25-yl] (~{E})-2-methylbut-2-enoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303