8DO0: Cryo-EM structure of the human Sec61 complex inhibited by mycolactone

PDB ID: 8DO0Download
MMDB ID: 230530
PDB Deposition Date: 2022/7/12
Updated in MMDB: 2023/09
Experimental Method:
electron microscopy
Resolution: 2.86  Å
Source Organism:
Similar Structures:
Biological Unit for 8DO0: trimeric; determined by author
Molecular Components in 8DO0
Label Count Molecule
Proteins (3 molecules)
1
Protein Transport Protein Sec61 Subunit Gamma
(Gene symbol: SEC61G)
Molecule annotation
1
Protein Transport Protein Sec61 Subunit Beta
(Gene symbol: SEC61B)
Molecule annotation
1
Protein Transport Protein Sec61 Subunit Alpha Isoform 1
(Gene symbol: SEC61A1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
[(6~{S},7~{S},9~{Z},12~{R})-12-[(~{Z},2~{S},6~{R},7~{R},9~{R})-4,6-dimethyl-7,9-bis(oxidanyl)dec-4-en-2-yl]-7,9-dimethyl-2-oxidanylidene-1-oxacyclododec-9-en-6-yl] (2~{E},4~{E},6~{E},8~{E},10~{E},12~{S},13~{S},15~{S})-4,6,10-trimethyl-12,13,15-tris(oxidanyl)hexadeca-2,4,6,8,10-pentaenoate[(6~{S},7~{S},9~{Z},12~{R})-12-[(~{Z},2~{S},6~{R},7~{R},9~{R})-4,6-dimethyl-7,9-bis(oxidanyl)dec-4-en-2-yl]-7,9-dimethyl-2-oxidanylidene-1-oxacyclododec-9-en-6-yl] (2~{E},4~{E},6~{E},8~{E},10~{E},12~{S},13~{S},15~{S})-4,6,10-trimethyl-12,13,15-tris(oxidanyl)hexadeca-2,4,6,8,10-pentaenoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303