8DGS: Cryo-EM structure of a RAS/RAF complex (state 1)

PDB ID: 8DGSDownload
MMDB ID: 232399
PDB Deposition Date: 2022/6/24
Updated in MMDB: 2023/08
Experimental Method:
electron microscopy
Resolution: 4.3  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 8DGS: pentameric; determined by author
Molecular Components in 8DGS
Label Count Molecule
Proteins (5 molecules)
1
Serine/threonine-protein Kinase B-raf
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
Molecule annotation
2
14-3-3 Protein Zeta
Molecule annotation
1
Gtpase Kras Isoform X2
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTERPHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
2
2
ZINC IONZINC ION
3
2
MAGNESIUM IONMAGNESIUM ION
4
1
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
5
1
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303