8DEY: Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709

PDB ID: 8DEYDownload
MMDB ID: 227609
PDB Deposition Date: 2022/6/21
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 3.7  Å
Source Organism:
Similar Structures:
Biological Unit for 8DEY: trimeric; determined by author
Molecular Components in 8DEY
Label Count Molecule
Proteins (3 molecules)
1
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
1
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
1
Zinc Finger Protein Helios
(Gene symbol: IKZF2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
3
ZINC IONZINC ION
2
1
(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303