8CZ8: Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics

PDB ID: 8CZ8Download
MMDB ID: 231127
PDB Deposition Date: 2022/5/24
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8CZ8: trimeric; determined by author and by software (PISA)
Molecular Components in 8CZ8
Label Count Molecule
Proteins (3 molecules)
1
Scfv Anetumab
Molecule annotation
1
Mesothelin, Cleaved Form
(Gene symbol: MSLN)
Molecule annotation
1
Scfv of A12 Anti-mesothelin Antibody
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303