8CYI: Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5

PDB ID: 8CYIDownload
MMDB ID: 228961
PDB Deposition Date: 2022/5/23
Updated in MMDB: 2024/06
Experimental Method:
electron microscopy
Resolution: 3.14  Å
Source Organism:
Similar Structures:
Biological Unit for 8CYI: dimeric; determined by author
Molecular Components in 8CYI
Label Count Molecule
Proteins (2 molecules)
1
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
1
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamideN-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
2
1
5'-DEOXY-5'-METHYLTHIOADENOSINE5'-DEOXY-5'-METHYLTHIOADENOSINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303