8CO7: Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066

PDB ID: 8CO7Download
MMDB ID: 240806
PDB Deposition Date: 2023/2/27
Updated in MMDB: 2024/01
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8CO7: monomeric; determined by author
Molecular Components in 8CO7
Label Count Molecule
Protein (1 molecule)
1
Adenylate Cyclase Type 10
(Gene symbol: ADCY10)
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
1
4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine
2
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
5
ACETATE IONACETATE ION
4
6
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
6
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
7
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303