8CNO: Improved complex structure of human Sirtuin 6 with its inhibitor cis-resveratrol

PDB ID: 8CNODownload
MMDB ID: 243512
PDB Deposition Date: 2023/2/23
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 8CNO: dimeric; determined by author
Molecular Components in 8CNO
Label Count Molecule
Proteins (2 molecules)
2
Nad-dependent Protein Deacetylase Sirtuin-6
(Gene symbol: SIRT6)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
2
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
2
2
ZINC IONZINC ION
3
2
RESVERATROLRESVERATROL
4
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
5
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
9
SULFATE IONSULFATE ION
7
6
CHLORIDE IONCHLORIDE ION
8
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
9
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303