8CJM: Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047

PDB ID: 8CJMDownload
MMDB ID: 240962
PDB Deposition Date: 2023/2/13
Updated in MMDB: 2024/01
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8CJM: monomeric; determined by author and by software (PISA)
Molecular Components in 8CJM
Label Count Molecule
Protein (1 molecule)
1
Tryptophan 5-hydroxylase 1
(Gene symbol: TPH1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
FE (III) IONFE (III) ION
2
1
7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303