8CIE: Crystal structure of the human CDKL5 kinase domain with compound YL-354

PDB ID: 8CIEDownload
MMDB ID: 231626
PDB Deposition Date: 2023/2/9
Updated in MMDB: 2023/06
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8CIE: monomeric; determined by author
Molecular Components in 8CIE
Label Count Molecule
Protein (1 molecule)
1
Cyclin-dependent Kinase-like 5
(Gene symbol: CDKL5)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
4-[[3,5-bis(fluoranyl)phenyl]carbonylamino]-~{N}-piperidin-4-yl-1~{H}-pyrazole-3-carboxamide4-[[3,5-bis(fluoranyl)phenyl]carbonylamino]-~{N}-piperidin-4-yl-1~{H}-pyrazole-3-carboxamide
2
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303