8CGW: Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor

PDB ID: 8CGWDownload
MMDB ID: 241915
PDB Deposition Date: 2023/2/6
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 3.03  Å
Source Organism:
Similar Structures:
Biological Unit for 8CGW: monomeric; determined by author
Molecular Components in 8CGW
Label Count Molecule
Protein (1 molecule)
1
Leucyl-cystinyl Aminopeptidase, Pregnancy Serum Form
(Gene symbol: LNPEP)
Molecule annotation
Chemicals and Non-standard biopolymers (23 molecules)
1
16
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
1
alpha-D-mannopyranosealpha-D-mannopyranose
4
1
ZINC IONZINC ION
5
1
ethyl 2-acetamido-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylateethyl 2-acetamido-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylate
6
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
7
2
GLYCINEGLYCINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303