8CGP: Insulin regulated aminopeptidase (IRAP) in complex with an allosteric aryl sulfonamide inhibitor

PDB ID: 8CGPDownload
MMDB ID: 241914
PDB Deposition Date: 2023/2/6
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.62  Å
Source Organism:
Similar Structures:
Biological Unit for 8CGP: monomeric; determined by author
Molecular Components in 8CGP
Label Count Molecule
Protein (1 molecule)
1
Leucyl-cystinyl Aminopeptidase, Pregnancy Serum Form
(Gene symbol: LNPEP)
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
16
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
3
alpha-D-mannopyranosealpha-D-mannopyranose
4
1
D-MALATED-MALATE
5
1
ZINC IONZINC ION
6
1
4-bromanyl-5-chloranyl-~{N}-[3-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide4-bromanyl-5-chloranyl-~{N}-[3-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide
7
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
8
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303