8CDG: Crystal structure of human IL-17A cytokine in complex with macrocycle

PDB ID: 8CDGDownload
MMDB ID: 239315
PDB Deposition Date: 2023/1/30
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8CDG: dimeric; determined by author and by software (PISA)
Molecular Components in 8CDG
Label Count Molecule
Proteins (2 molecules)
2
Interleukin-17a
(Gene symbol: IL17A)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid(9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303