8CBU: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT884

PDB ID: 8CBUDownload
MMDB ID: 231116
PDB Deposition Date: 2023/1/25
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 2.44  Å
Source Organism:
Similar Structures:
Biological Unit for 8CBU: tetrameric; determined by author
Molecular Components in 8CBU
Label Count Molecule
Proteins (4 molecules)
4
Integrase
(Gene symbol: gag-pol)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
CHLORIDE IONCHLORIDE ION
2
7
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
2
(2S)-2-[3-cyclopropyl-6-methyl-2-(5-methyl-3,4-dihydro-2H-chromen-6-yl)phenyl]-2-cyclopropyloxy-ethanoic acid(2S)-2-[3-cyclopropyl-6-methyl-2-(5-methyl-3,4-dihydro-2H-chromen-6-yl)phenyl]-2-cyclopropyloxy-ethanoic acid
4
2
MAGNESIUM IONMAGNESIUM ION
5
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303