8CBT: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT872

PDB ID: 8CBTDownload
MMDB ID: 231115
PDB Deposition Date: 2023/1/25
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 2.14  Å
Source Organism:
Similar Structures:
Biological Unit for 8CBT: tetrameric; determined by author and by software (PISA)
Molecular Components in 8CBT
Label Count Molecule
Proteins (4 molecules)
4
Integrase
(Gene symbol: gag-pol)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
2
(2~{S})-2-[3-cyclopropyl-2-(3,4-dihydro-2~{H}-chromen-6-yl)-6-methyl-phenyl]-2-cyclopropyloxy-ethanoic acid(2~{S})-2-[3-cyclopropyl-2-(3,4-dihydro-2~{H}-chromen-6-yl)-6-methyl-phenyl]-2-cyclopropyloxy-ethanoic acid
2
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
2
MAGNESIUM IONMAGNESIUM ION
4
4
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303