8CB6: Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in covalent complex with TAMRA tagged 1,6-Epi-cylcophellitol aziridine activity based probe

PDB ID: 8CB6Download
MMDB ID: 235407
PDB Deposition Date: 2023/1/25
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8CB6: dimeric; determined by author and by software (PISA)
Molecular Components in 8CB6
Label Count Molecule
Proteins (2 molecules)
1
Lysosomal Alpha-glucosidase (76 Kda)
(Gene symbol: GAA)
Molecule annotation
1
Lysosomal Alpha-glucosidase (70 Kda)
(Gene symbol: GAA)
Molecule annotation
Chemicals and Non-standard biopolymers (41 molecules)
1
9
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
alpha-L-fucopyranosealpha-L-fucopyranose
3
1
beta-D-mannopyranosebeta-D-mannopyranose
4
10
CHLORIDE IONCHLORIDE ION
5
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
4
GLYCEROLGLYCEROL
7
1
(1S,2R,3R,4R,5R)-5-[8-[4-(4-azanylbutyl)-1,2,3-triazol-1-yl]octylamino]-4-(hydroxymethyl)cyclohexane-1,2,3-triol(1S,2R,3R,4R,5R)-5-[8-[4-(4-azanylbutyl)-1,2,3-triazol-1-yl]octylamino]-4-(hydroxymethyl)cyclohexane-1,2,3-triol
8
4
SULFATE IONSULFATE ION
9
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303