8CB1: Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-PNT-DNM 15

PDB ID: 8CB1Download
MMDB ID: 235406
PDB Deposition Date: 2023/1/25
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 8CB1: dimeric; determined by author and by software (PISA)
Molecular Components in 8CB1
Label Count Molecule
Proteins (2 molecules)
1
Lysosomal Alpha-glucosidase (76 Kda)
(Gene symbol: GAA)
Molecule annotation
1
Lysosomal Alpha-glucosidase (70 Kda)
(Gene symbol: GAA)
Molecule annotation
Chemicals and Non-standard biopolymers (41 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-L-fucopyranosealpha-L-fucopyranose
4
10
CHLORIDE IONCHLORIDE ION
5
4
GLYCEROLGLYCEROL
6
3
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
7
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
8
1
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol
9
4
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303