8C9U: Crystal structure of SARS-CoV-2 Mpro-Q189K mutant in complex with nirmatrelvir

PDB ID: 8C9UDownload
MMDB ID: 250600
PDB Deposition Date: 2023/1/23
Updated in MMDB: 2025/09
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 8C9U: dimeric; determined by author and by software (PISA)
Molecular Components in 8C9U
Label Count Molecule
Proteins (2 molecules)
2
Non-structural Protein 11
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303