8C41: High resolution structure of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin

PDB ID: 8C41Download
MMDB ID: 240955
PDB Deposition Date: 2022/12/30
Updated in MMDB: 2025/08
Experimental Method:
x-ray diffraction
Resolution: 2.393  Å
Source Organism:
DNA molecule▼
Similar Structures:
Biological Unit for 8C41: hexameric; determined by author and by software (PISA)
Molecular Components in 8C41
Label Count Molecule
Proteins (2 molecules)
2
Fused Pare30parc55 Cleavage Complex of the Topoisomerase IV
Molecule annotation
Nucleotides(4 molecules)
1
DNA (5'-d(*cp*ap*tp*gp*ap*ap*t)-3')
Molecule annotation
1
DNA (5'-d(p*ap*gp*tp*cp*ap*tp*tp*cp*ap*tp*g)-3')
Molecule annotation
1
DNA (5'-d(*cp*gp*tp*gp*cp*ap*t)-3')
Molecule annotation
1
DNA (5'-d(p*gp*ap*cp*tp*ap*tp*gp*cp*ap*cp*g)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
3
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
2
6
MAGNESIUM IONMAGNESIUM ION
3
2
CHLORIDE IONCHLORIDE ION
4
2
delafloxacindelafloxacin
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303