8C1H: Aurora A kinase in complex with TPX2-inhibitor 8

PDB ID: 8C1HDownload
MMDB ID: 240934
PDB Deposition Date: 2022/12/20
Updated in MMDB: 2024/09
Experimental Method:
x-ray diffraction
Resolution: 2.233  Å
Source Organism:
Similar Structures:
Biological Unit for 8C1H: monomeric; determined by author and by software (PISA)
Molecular Components in 8C1H
Label Count Molecule
Protein (1 molecule)
1
Aurora Kinase a
(Gene symbol: AURKA)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
1
4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide
2
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
3
2
MAGNESIUM IONMAGNESIUM ION
4
1
(1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid(1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid
5
5
SULFATE IONSULFATE ION
6
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
7
1
ACETATE IONACETATE ION
8
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303