8BU2: Structure of DDB1 bound to DS18-engaged CDK12-cyclin K

PDB ID: 8BU2Download
MMDB ID: 235376
PDB Deposition Date: 2022/11/30
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 3.13  Å
Source Organism:
Similar Structures:
Biological Unit for 8BU2: trimeric; determined by author
Molecular Components in 8BU2
Label Count Molecule
Proteins (3 molecules)
1
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
1
Cyclin-dependent Kinase 12
(Gene symbol: CDK12)
Molecule annotation
1
Cyclin-k
(Gene symbol: CCNK)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
12
SULFATE IONSULFATE ION
2
1
~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-2-morpholin-4-yl-9-propan-2-yl-purin-6-amine~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-2-morpholin-4-yl-9-propan-2-yl-purin-6-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303