8BR7: Discovery of IRAK4 Inhibitors BAY1834845 and BAY1830839

PDB ID: 8BR7Download
MMDB ID: 241900
PDB Deposition Date: 2022/11/22
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.119  Å
Source Organism:
Similar Structures:
Biological Unit for 8BR7: monomeric; determined by author
Molecular Components in 8BR7
Label Count Molecule
Protein (1 molecule)
1
Interleukin-1 Receptor-associated Kinase 4
(Gene symbol: IRAK4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-nitro-~{N}-[2-[2-oxidanylidene-2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl]indazol-5-yl]benzamide3-nitro-~{N}-[2-[2-oxidanylidene-2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl]indazol-5-yl]benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303