8BN8: METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006

PDB ID: 8BN8Download
MMDB ID: 235734
PDB Deposition Date: 2022/11/13
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.213  Å
Source Organism:
Similar Structures:
Biological Unit for 8BN8: dimeric; determined by author and by software (PISA)
Molecular Components in 8BN8
Label Count Molecule
Proteins (2 molecules)
1
N6-adenosine-methyltransferase Catalytic Subunit
(Gene symbol: METTL3)
Molecule annotation
1
N6-adenosine-methyltransferase Non-catalytic Subunit
(Gene symbol: METTL14)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303