8BL0: Human Sirt6 in complex with the inhibitor S6023 and ADP-ribose

PDB ID: 8BL0Download
MMDB ID: 238694
PDB Deposition Date: 2022/11/9
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.82  Å
Source Organism:
Similar Structures:
Biological Unit for 8BL0: monomeric; determined by author
Molecular Components in 8BL0
Label Count Molecule
Protein (1 molecule)
1
Nad-dependent Protein Deacetylase Sirtuin-6
(Gene symbol: SIRT6)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
2
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
2
1
ZINC IONZINC ION
3
1
3-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonylbenzenesulfonamide3-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonylbenzenesulfonamide
4
6
SULFATE IONSULFATE ION
5
3
CHLORIDE IONCHLORIDE ION
6
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303