National Center for
Biotechnology Information

8BDF: Tubulin-taxane-2a complex

PDB ID:

MMDB ID:

228052

PDB Deposition Date:

2022/10/19

Updated in MMDB:

2023/03

Experimental Method:

x-ray diffraction

Resolution:

1.95 Å

Source Organism:

Rattus norvegicus▼

Similar Structures:

Biological Unit for 8BDF: hexameric; determined by author and by software (PISA)

Molecular Components in 8BDF
Label	Count	Molecule
Proteins (6 molecules)
A C	2	Tubulin Alpha-1b Chain
B D	2	Tubulin Beta-2b Chain
E	1	Stathmin-4
F	1	Tubulin Beta-2b Chain
Chemicals and Non-standard biopolymers (14 molecules)
1	2	GUANOSINE-5'-TRIPHOSPHATE
2	5	MAGNESIUM ION
3	1	CALCIUM ION
4	2	GUANOSINE-5'-DIPHOSPHATE
5	1	2-(N-MORPHOLINO)-ETHANESULFONIC ACID
6	2	[(1~{S},2~{S},3~{R},4~{S},7~{R},9~{S},10~{S},12~{R},15~{S})-4-acetyloxy-15-[(2~{R},3~{S})-3-[(4-methoxy-2-methylidene-4-oxidanylidene-butanoyl)amino]-2-oxidanyl-3-phenyl-propanoyl]oxy-10,14,16,16-tetramethyl-1,9,12-tris(oxidanyl)-11-oxidanylidene-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl] benzoate $[(1~{S},2~{S},3~{R},4~{S},7~{R},9~{S},10~{S},12~{R},15~{S})-4-acetyloxy-15-[(2~{R},3~{S})-3-[(4-methoxy-2-methylidene-4-oxidanylidene-butanoyl)amino]-2-oxidanyl-3-phenyl-propanoyl]oxy-10,14,16,16-tetramethyl-1,9,12-tris(oxidanyl)-11-oxidanylidene-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl] benzoate$
7	1	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER

* Click molecule labels to explore molecular sequence information.

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