National Center for
Biotechnology Information

8B7C: Tubulin-maytansinoid-12 complex

PDB ID:

MMDB ID:

234459

PDB Deposition Date:

2022/9/29

Updated in MMDB:

2023/08

Experimental Method:

x-ray diffraction

Resolution:

1.9 Å

Source Organism:

Rattus norvegicus▼

Similar Structures:

Biological Unit for 8B7C: hexameric; determined by author and by software (PISA)

Molecular Components in 8B7C
Label	Count	Molecule
Proteins (6 molecules)
A C	2	Tubulin Alpha-1b Chain
B D	2	Tubulin Beta-2b Chain
E	1	Stathmin-4
F	1	Tubulin Tyrosine Ligase
Chemicals and Non-standard biopolymers (17 molecules)
1	2	GUANOSINE-5'-TRIPHOSPHATE
2	5	MAGNESIUM ION
3	4	CALCIUM ION
4	1	IMIDAZOLE
5	2	GUANOSINE-5'-DIPHOSPHATE
6	1	2-(N-MORPHOLINO)-ETHANESULFONIC ACID
7	1	[(1~{S},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl] 4-[2-(2-azanylhydrazinyl)ethyl]benzoate $[(1~{S},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl] 4-[2-(2-azanylhydrazinyl)ethyl]benzoate$
8	1	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER

* Click molecule labels to explore molecular sequence information.

Citing MMDB