National Center for
Biotechnology Information

8B7A: Tubulin - maytansinoid - 4 complex

PDB ID:

MMDB ID:

234457

PDB Deposition Date:

2022/9/29

Updated in MMDB:

2023/08

Experimental Method:

x-ray diffraction

Resolution:

2.25 Å

Source Organism:

Rattus norvegicus▼

Similar Structures:

Biological Unit for 8B7A: hexameric; determined by author and by software (PISA)

Molecular Components in 8B7A
Label	Count	Molecule
Proteins (6 molecules)
A C	2	Tubulin Alpha-1b Chain
B D	2	Tubulin Beta-2b Chain
E	1	Stathmin-4
F	1	Tubulin Tyrosine Ligase
Chemicals and Non-standard biopolymers (19 molecules)
1	2	GUANOSINE-5'-TRIPHOSPHATE
2	6	MAGNESIUM ION
3	5	CALCIUM ION
4	1	IMIDAZOLE
5	2	GUANOSINE-5'-DIPHOSPHATE
6	1	2-(N-MORPHOLINO)-ETHANESULFONIC ACID
7	1	[(1~{R},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl] pent-4-enoate $[(1~{R},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl] pent-4-enoate$
8	1	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER

* Click molecule labels to explore molecular sequence information.

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