8AZZ: KRAS-G12V in complex with BI-2865

PDB ID: 8AZZDownload
MMDB ID: 231849
PDB Deposition Date: 2022/9/6
Updated in MMDB: 2023/07
Experimental Method:
x-ray diffraction
Resolution: 1.02  Å
Source Organism:
Similar Structures:
Biological Unit for 8AZZ: monomeric; determined by author and by software (PISA)
Molecular Components in 8AZZ
Label Count Molecule
Protein (1 molecule)
1
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
MAGNESIUM IONMAGNESIUM ION
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303