8AYO: Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059

PDB ID: 8AYODownload
MMDB ID: 229205
PDB Deposition Date: 2022/9/2
Updated in MMDB: 2023/05
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 8AYO: hexameric; determined by author
Molecular Components in 8AYO
Label Count Molecule
Proteins (6 molecules)
2
Isoform Flip of Glutamate Receptor 1
(Gene symbol: Gria1)
Molecule annotation
2
Isoform Flip of Glutamate Receptor 2
(Gene symbol: Gria2)
Molecule annotation
2
Voltage-dependent Calcium Channel Gamma-8 Subunit
(Gene symbol: Cacng8)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
4
GLUTAMIC ACIDGLUTAMIC ACID
2
4
CYCLOTHIAZIDECYCLOTHIAZIDE
3
4
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
4
10
PALMITIC ACIDPALMITIC ACID
5
2
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
6
2
5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303