8AX3: Structure of recombinant human beta-glucocerebrosidase in complex with L-carbaxylosyl fluoride

PDB ID: 8AX3Download
MMDB ID: 243886
PDB Deposition Date: 2022/8/30
Updated in MMDB: 2026/03
Experimental Method:
x-ray diffraction
Resolution: 1.59  Å
Source Organism:
Similar Structures:
Biological Unit for 8AX3: dimeric; determined by author
Molecular Components in 8AX3
Label Count Molecule
Proteins (2 molecules)
2
Lysosomal Acid Glucosylceramidase
(Gene symbol: GBA)
Molecule annotation
Chemicals and Non-standard biopolymers (70 molecules)
1
8
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
beta-D-mannopyranosebeta-D-mannopyranose
3
6
SULFATE IONSULFATE ION
4
47
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
4
(1~{S},2~{R},3~{S},6~{S})-6-fluoranylcyclohex-4-ene-1,2,3-triol(1~{S},2~{R},3~{S},6~{S})-6-fluoranylcyclohex-4-ene-1,2,3-triol
6
1
SODIUM IONSODIUM ION
7
1
GLYCEROLGLYCEROL
8
1
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303