8AV0: small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3

PDB ID: 8AV0Download
MMDB ID: 229514
PDB Deposition Date: 2022/8/26
Updated in MMDB: 2023/06
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 8AV0: tetrameric; determined by author
Molecular Components in 8AV0
Label Count Molecule
Proteins (4 molecules)
2
14-3-3 Protein Sigma
(Gene symbol: SFN)
Molecule annotation
2
RAF Proto-oncogene Serine/threonine-protein Kinase
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
CHLORIDE IONCHLORIDE ION
2
6
MAGNESIUM IONMAGNESIUM ION
3
2
1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303