8AU5: c-MET F1200I mutant in complex with Tepotinib

PDB ID: 8AU5Download
MMDB ID: 235058
PDB Deposition Date: 2022/8/25
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.72  Å
Source Organism:
Similar Structures:
Biological Unit for 8AU5: monomeric; determined by author
Molecular Components in 8AU5
Label Count Molecule
Protein (1 molecule)
1
Hepatocyte Growth Factor Receptor
(Gene symbol: MET)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile
2
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303