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8AFN:
Small molecule stabilizer (compound 1) for ERalpha and 14-3-3
PDB ID:
8AFN
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MMDB ID:
229505
PDB Deposition Date:
2022/7/18
Updated in MMDB:
2023/06
Experimental Method:
x-ray diffraction
Resolution:
1.36 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 8AFN: tetrameric; determined by author
Molecular Components in 8AFN
Label
Count
Molecule
Proteins (4 molecules)
A
A_1
2
14-3-3 Protein Sigma
(Gene symbol:
SFN
)
B
B_1
2
Estrogen Receptor
Chemicals and Non-standard biopolymers (4 molecules)
1
2
MAGNESIUM ION
2
2
1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303