8AE9: Human Aldose Reductase in Complex with a Hydroxyphenyl-Thiophen-Acid Inhibitor (Schl32357)

PDB ID: 8AE9Download
MMDB ID: 234091
PDB Deposition Date: 2022/7/12
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 0.95  Å
Source Organism:
Similar Structures:
Biological Unit for 8AE9: monomeric; determined by author
Molecular Components in 8AE9
Label Count Molecule
Protein (1 molecule)
1
Aldose Reductase
(Gene symbol: AKR1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
5-(5-(3-hydroxyphenyl)thiophen-2-yl)pentanoic acid5-(5-(3-hydroxyphenyl)thiophen-2-yl)pentanoic acid
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303