8A6F: Small molecule stabilizer (compound 8) for C-RAF and 14-3-3

PDB ID: 8A6FDownload
MMDB ID: 229489
PDB Deposition Date: 2022/6/17
Updated in MMDB: 2023/06
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8A6F: tetrameric; determined by author and by software (PISA)
Molecular Components in 8A6F
Label Count Molecule
Proteins (4 molecules)
2
14-3-3 Protein Sigma
(Gene symbol: SFN)
Molecule annotation
2
RAF Proto-oncogene Serine/threonine-protein Kinase
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
CHLORIDE IONCHLORIDE ION
2
4
MAGNESIUM IONMAGNESIUM ION
3
2
1-[4-[4-chloranyl-3-(trifluoromethyl)phenyl]-4-oxidanyl-piperidin-1-yl]-3-[2-(dimethylamino)ethyldisulfanyl]propan-1-one1-[4-[4-chloranyl-3-(trifluoromethyl)phenyl]-4-oxidanyl-piperidin-1-yl]-3-[2-(dimethylamino)ethyldisulfanyl]propan-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303