8A68: Small molecule stabilizer (compound 5) for C-RAF(pS259) and 14-3-3

PDB ID: 8A68Download
MMDB ID: 229488
PDB Deposition Date: 2022/6/16
Updated in MMDB: 2023/06
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8A68: tetrameric; determined by author
Molecular Components in 8A68
Label Count Molecule
Proteins (4 molecules)
2
14-3-3 Protein Sigma
(Gene symbol: SFN)
Molecule annotation
2
RAF Proto-oncogene Serine/threonine-protein Kinase
(Gene symbol: RAF1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
4
MAGNESIUM IONMAGNESIUM ION
2
2
~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-1-[(2~{R})-2-(6-methoxynaphthalen-2-yl)propanoyl]piperidine-4-carboxamide~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-1-[(2~{R})-2-(6-methoxynaphthalen-2-yl)propanoyl]piperidine-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303