8A15: Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2230

PDB ID: 8A15Download
MMDB ID: 231575
PDB Deposition Date: 2022/5/31
Updated in MMDB: 2024/06
Experimental Method:
x-ray diffraction
Resolution: 1.23  Å
Source Organism:
Similar Structures:
Biological Unit for 8A15: dimeric; determined by author
Molecular Components in 8A15
Label Count Molecule
Proteins (2 molecules)
1
Serine Protease Subunit Ns2b
Molecule annotation
1
Serine Protease NS3
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-[(8~{R},15~{S},18~{S})-15-(4-azanylbutyl)-18-(naphthalen-2-ylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine1-[(8~{R},15~{S},18~{S})-15-(4-azanylbutyl)-18-(naphthalen-2-ylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303