7ZI7: Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0345 inhibitor

PDB ID: 7ZI7Download
MMDB ID: 231060
PDB Deposition Date: 2022/4/7
Updated in MMDB: 2023/06
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 7ZI7: dimeric; determined by author and by software (PISA)
Molecular Components in 7ZI7
Label Count Molecule
Proteins (2 molecules)
2
Deoxycytidine Kinase
(Gene symbol: DCK)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
URIDINE-5'-DIPHOSPHATEURIDINE-5'-DIPHOSPHATE
2
2
4-(4-azanylpyrimidin-2-yl)-N-[2-methyl-5-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]phenyl]-N-propyl-1,3-thiazol-2-amine4-(4-azanylpyrimidin-2-yl)-N-[2-methyl-5-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]phenyl]-N-propyl-1,3-thiazol-2-amine
3
2
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303