7YSU: Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex

PDB ID: 7YSUDownload
MMDB ID: 229140
PDB Deposition Date: 2022/8/13
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 7YSU: tetrameric; determined by author
Molecular Components in 7YSU
Label Count Molecule
Proteins (4 molecules)
1
Klotho
(Gene symbol: KL)
Molecule annotation
2
Fibroblast Growth Factor Receptor 3
(Gene symbol: FGFR3)
Molecule annotation
1
Fibroblast Growth Factor 23
(Gene symbol: FGF23)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
5
2-O-sulfo-alpha-L-idopyranuronic acid2-O-sulfo-alpha-L-idopyranuronic acid
2
5
2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose
3
1
ZINC IONZINC ION
4
1
COPPER (II) IONCOPPER (II) ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303