7YQ8: Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide

PDB ID: 7YQ8Download
MMDB ID: 240804
PDB Deposition Date: 2022/8/5
Updated in MMDB: 2025/06
Experimental Method:
electron microscopy
Resolution: 3.9  Å
Source Organism:
Similar Structures:
Biological Unit for 7YQ8: hexameric; determined by author
Molecular Components in 7YQ8
Label Count Molecule
Proteins (2 molecules)
2
DNA Topoisomerase 2-beta
(Gene symbol: TOP2B)
Molecule annotation
Nucleotides(4 molecules)
2
50-mer DNA
Molecule annotation
2
50-mer DNA
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
2
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303