7YG5: Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state

PDB ID: 7YG5Download
MMDB ID: 239080
PDB Deposition Date: 2022/7/11
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 7YG5: trimeric; determined by author
Molecular Components in 7YG5
Label Count Molecule
Proteins (3 molecules)
1
Voltage-dependent R-type Calcium Channel Subunit Alpha-1e
(Gene symbol: CACNA1E)
Molecule annotation
1
Voltage-dependent L-type Calcium Channel Subunit Beta-1
(Gene symbol: CACNB1)
Molecule annotation
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
(Gene symbol: CACNA2D1)
Molecule annotation
Chemicals and Non-standard biopolymers (37 molecules)
1
14
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
9
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
4
6
HEXADECANEHEXADECANE
5
2
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
6
2
CALCIUM IONCALCIUM ION
7
1
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303