7Y1W: Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1

PDB ID: 7Y1WDownload
MMDB ID: 232270
PDB Deposition Date: 2022/6/9
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 7Y1W: dimeric; determined by author and by software (PISA)
Molecular Components in 7Y1W
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Glutamate/proline--trna Ligase
(Gene symbol: EPRS1)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
ZINC IONZINC ION
2
2
(2R,3S)-2-[3-[4,5-bis(chloranyl)benzimidazol-1-yl]propyl]piperidin-3-ol(2R,3S)-2-[3-[4,5-bis(chloranyl)benzimidazol-1-yl]propyl]piperidin-3-ol
3
1
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
4
2
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303